Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly.

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly.

The structural features of the human IgA1 tailpiece required for interaction with J chain in IgA dimer assembly were investigated using a protein engineering approach. Wild-type and mutant forms of IgA1 were expressed in the mouse myeloma cell line, J558L, which endogenously expresses J chain. Wild-...

书目详细资料
Main Authors:	Atkin, J, Pleass, R, Owens, R, Woof, J
格式:	Journal article
语言:	English
出版:	1996

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