Development of a self-silencing adenovirus for the efficient manufacture of adeno-associated virus vectors
<p>Adeno-associated virus (AAV) shows great promise for gene therapy, however scalability, yield and quality remain significant issues. The most common ‘helper-free’ method used to produce recombinant AAV (rAAV) for pre-clinical/clinical application is based on plasmid transfection of HEK293 c...
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| Format: | Thesis |
| Language: | English |
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2021
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