Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.

We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the associati...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Scott, R, Fall, T, Pasko, D, Barker, A, Sharp, S, Arriola, L, Balkau, B, Barricarte, A, Barroso, I, Boeing, H, Clavel-Chapelon, F, Crowe, F, Dekker, J, Fagherazzi, G, Ferrannini, E, Forouhi, N, Franks, P, Gavrila, D, Giedraitis, V, Grioni, S, Groop, L, Kaaks, R, Key, T, Kühn, T, Lotta, L
Format: Journal article
Sprache:English
Veröffentlicht: 2014