Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

BACKGROUND:Abnormal accumulation of amyloid β1-42 oligomers (AβO1-42), a hallmark of Alzheimer's disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positive (...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Park, K, Lee, J, Jang, H, Richards, B, Kohl, M, Kwag, J
स्वरूप: Journal article
भाषा:English
प्रकाशित: BioMed Central 2020