Mechanisms of substrate processing during ER-associated protein degradation

Mechanisms of substrate processing during ER-associated protein degradation

Maintaining proteome integrity is essential for long-term viability of all organisms and is overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes poses a challenge for such quality assurance as proteins destined for secretion enter the endoplasmic reticulum (ER) and b...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Christianson, JC, Jarosch, E, Sommer, TJ
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Springer Nature 2023

Eitemau Tebyg

Order through destruction: how ER-associated protein degradation contributes to organelle homeostasis
gan: Christianson, JC, et al.
Cyhoeddwyd: (2022)

ER-Associated Degradation of Membrane Proteins in Yeast
gan: Cédric Pety de Thozée, et al.
Cyhoeddwyd: (2006-01-01)

EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog
gan: Tang, H, et al.
Cyhoeddwyd: (2014)

EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog.
gan: Hsiang-Yun Tang, et al.
Cyhoeddwyd: (2014-01-01)

Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
gan: Claudia C Schmidt, et al.
Cyhoeddwyd: (2020-06-01)

A new pathway for membrane protein insertion at the ER
gan: Guna, A, et al.
Cyhoeddwyd: (2018)

Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis
gan: Xiaoqiong Wei, et al.
Cyhoeddwyd: (2024-01-01)

The ER quality control and ER associated degradation machineries are vital for viral pathogenesis
gan: Jeanmarie eVerchot
Cyhoeddwyd: (2014-03-01)

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase
gan: Greenblatt, Wesley H., et al.
Cyhoeddwyd: (2012)

The ER membrane protein complex is a transmembrane domain insertase
gan: Guna, A, et al.
Cyhoeddwyd: (2017)

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)
gan: Schulz, J, et al.
Cyhoeddwyd: (2017)

DangER: protein ovERload. Targeting protein degradation to treat myeloma
gan: Lauren I. Aronson, et al.
Cyhoeddwyd: (2012-08-01)

Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins
gan: Ng, Benjamin S. H., et al.
Cyhoeddwyd: (2019)

Forskolin Stimulates Estrogen Receptor (ER) α Transcriptional Activity and Protects ER from Degradation by Distinct Mechanisms
gan: Houng-Wei Tsai, et al.
Cyhoeddwyd: (2022-01-01)

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery
gan: Zev A Ripstein, et al.
Cyhoeddwyd: (2020-01-01)

ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine
gan: Varsha Venkatarangan, et al.
Cyhoeddwyd: (2023-10-01)

The mammalian endoplasmic reticulum-associated degradation system.
gan: Olzmann, J, et al.
Cyhoeddwyd: (2013)

Ni-YSZ Substrate Degradation during Carbon Deposition
gan: Marinšek, Marjan
Cyhoeddwyd: (2011-06-01)

Counting Degrons: Lessons From Multivalent Substrates for Targeted Protein Degradation
gan: Cynthia N. Okoye, et al.
Cyhoeddwyd: (2022-07-01)

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation
gan: Yicheng Wang, et al.
Cyhoeddwyd: (2020-02-01)

Altered methylation and expression of ER-associated degradation factors in long-term alcohol and constitutive ER stress-induced murine hepatic tumors
gan: Hui eHan, et al.
Cyhoeddwyd: (2013-10-01)

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2.
gan: Tom Cremer, et al.
Cyhoeddwyd: (2024-01-01)

Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2
gan: Tom Cremer, et al.
Cyhoeddwyd: (2024-01-01)

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.
gan: Hyo-Jin Park, et al.
Cyhoeddwyd: (2017-01-01)

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)
gan: Tian-Li Duan, et al.
Cyhoeddwyd: (2020-01-01)

ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface.
gan: Melisa C Monteleone, et al.
Cyhoeddwyd: (2012-01-01)

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis
gan: Volkmar, N, et al.
Cyhoeddwyd: (2018)

Integration of ER protein quality-control mechanisms defines β cell function and ER architecture
gan: Neha Shrestha, et al.
Cyhoeddwyd: (2023-02-01)

The influence of the association patterns of phosphorus–substrates and xylene–substrates on the degradation of xylenes in an alluvial aquifer
gan: SANJA MRKIC, et al.
Cyhoeddwyd: (2005-12-01)

The influence of the association patterns of phosphorus-substrates and xylene-substrates on the degradation of xylenes in an alluvial aquifer
gan: Mrkić Sanja, et al.
Cyhoeddwyd: (2005-01-01)

Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis
gan: Volkmar, N, et al.
Cyhoeddwyd: (2020)

Proteomics Identifies Substrates and a Novel Component in hSnd2-Dependent ER Protein Targeting
gan: Andrea Tirincsi, et al.
Cyhoeddwyd: (2022-09-01)

Protein Translocation Acquires Substrate Selectivity Through ER Stress-Induced Reassembly of Translocon Auxiliary Components
gan: Sohee Lee, et al.
Cyhoeddwyd: (2020-02-01)

Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import
gan: Sven Lang, et al.
Cyhoeddwyd: (2022-07-01)

Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation
gan: Zhihao Sun, et al.
Cyhoeddwyd: (2021-09-01)

UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR
gan: Yuka Kamada, et al.
Cyhoeddwyd: (2023-11-01)

The Targeting of Native Proteins to the Endoplasmic Reticulum-Associated Degradation (ERAD) Pathway: An Expanding Repertoire of Regulated Substrates
gan: Deepa Kumari, et al.
Cyhoeddwyd: (2021-08-01)

Mechanism of membrane-curvature generation by ER-tubule shaping proteins
gan: Ning Wang, et al.
Cyhoeddwyd: (2021-01-01)

Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2
gan: Xiaoan Wei, et al.
Cyhoeddwyd: (2022-05-01)

COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
gan: Navit Ogen-Shtern, et al.
Cyhoeddwyd: (2023-03-01)