Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence that IL-22 primed intestinal organoids derived from healthy human induced...

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Bibliographic Details
Main Authors: Forbester, J, Lees, E, Goulding, D, Forrest, S, Yeung, A, Speak, A, Clare, S, Coomber, E, Mukhopadhyay, S, Kraiczy, J, Schreiber, F, Lawley, T, Hancock, R, Uhlig, H, Zilbauer, M, Powrie, F, Dougan, G
Format: Journal article
Language:English
Published: National Academy of Sciences 2018