Proteomic analysis of tendon extracellular matrix reveals disease stage-specific fragmentation and differential cleavage of COMP (cartilage oligomeric matrix protein).

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint diseases than tendinopathy even though the pathoge...

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Bibliographic Details
Main Authors: Dakin, S, Smith, R, Heinegård, D, Önnerfjord, P, Khabut, A, Dudhia, J
Format: Journal article
Language:English
Published: 2014