Experimental epothilone B neurotoxicity: results of in vitro and in vivo studies.

Epothilones are a novel class of microtubule-targeting anticancer agents that are neurotoxic. In this study, we investigated the epothilone B toxic effect in vitro and we characterized in vivo the general and neurological side effects of epothilone B administration in Wistar and Fischer rats. The in...

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Bibliographic Details
Main Authors: Chiorazzi, A, Nicolini, G, Canta, A, Oggioni, N, Rigolio, R, Cossa, G, Lombardi, R, Roglio, I, Cervellini, I, Lauria, G, Melcangi, R, Bianchi, R, Crippa, D, Cavaletti, G
Format: Journal article
Language:English
Published: 2009