Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species.

Histone methyltransferase inhibitors: orally bioavailable, fast acting molecules with activity against different human malaria species.

Current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone methyltransferase inhibitor BIX-01294 and its analogue TM2-115. Here we further characteri...

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Bibliographic Details
Main Authors: Malmquist, N, Sundriyal, S, Caron, J, Chen, P, Witkowski, B, Menard, D, Suwanarusk, R, Renia, L, Nosten, F, Jiménez-Díaz, M, Angulo-Barturen, I, Martínez, MS, Ferrer, S, Sanz, L, Gamo, F, Wittlin, S, Duffy, S, Avery, V, Ruecker, A, Delves, M, Sinden, R, Fuchter, M, Scherf, A
Format: Journal article
Language:English
Published: 2014

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