In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases

In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases

The thioenol ML302F was recently identified as an inhibitor of class B metallo-β-lactamases (MBLs). We assessed the activity of ML302F when combined with meropenem (MEM) against 31 carbapenem resistant Gram-negative clinical isolates. Minimum inhibitory concentrations of MEM:ML302F were determined a...

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Detalles Bibliográficos
Main Authors:	Betts, J, Phee, L, Abdul Momin, M, Umland, K, Brem, J, Schofield, C, Wareham, D
Formato:	Journal article
Publicado:	Royal Society of Chemistry 2015

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