In vitro and in vivo activity of ML302F: a thioenolate inhibitor of VIM-subfamily metallo β-lactamases
The thioenol ML302F was recently identified as an inhibitor of class B metallo-β-lactamases (MBLs). We assessed the activity of ML302F when combined with meropenem (MEM) against 31 carbapenem resistant Gram-negative clinical isolates. Minimum inhibitory concentrations of MEM:ML302F were determined a...
Հիմնական հեղինակներ: | Betts, J, Phee, L, Abdul Momin, M, Umland, K, Brem, J, Schofield, C, Wareham, D |
---|---|
Ձևաչափ: | Journal article |
Հրապարակվել է: |
Royal Society of Chemistry
2015
|
Նմանատիպ նյութեր
-
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.
: Brem, J, և այլն
Հրապարակվել է: (2014) -
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
: Anka Lucic, և այլն
Հրապարակվել է: (2022-03-01) -
Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases
: Salimraj, R, և այլն
Հրապարակվել է: (2018) -
VIM-1 Metallo-β-lactamase in Acinetobacter baumannii
: Athanassios Tsakris, և այլն
Հրապարակվել է: (2006-06-01) -
Comparison of verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles
: Makena, A, և այլն
Հրապարակվել է: (2016)