Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had loss-of-function mutations in the gene encodi...
Prif Awduron: | , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
2009
|