Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had loss-of-function mutations in the gene encodi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Randall, K, Lambe, T, Johnson, A, Treanor, B, Kucharska, E, Domaschenz, H, Whittle, B, Tze, L, Enders, A, Crockford, T, Bouriez-Jones, T, Alston, D, Cyster, J, Lenardo, M, Mackay, F, Deenick, E, Tangye, S, Chan, T, Camidge, T, Brink, R, Vinuesa, C, Batista, F, Cornall, R, Goodnow, C
Format: Journal article
Sprache:English
Veröffentlicht: 2009

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