Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had loss-of-function mutations in the gene encodi...
Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , , , |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2009
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