O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib.

We evaluated the pharmacodynamic effects of the O(6)-methylguanine-DNA methyltransferase (MGMT) inactivator lomeguatrib (LM) on patients with melanoma in two clinical trials. Patients received temozolomide (TMZ) for 5 days either alone or with LM for 5, 10 or 14 days. Peripheral blood mononuclear ce...

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Autori principali: Watson, A, Middleton, MR, McGown, G, Thorncroft, M, Ranson, M, Hersey, P, McArthur, G, Davis, I, Thomson, D, Beith, J, Haydon, A, Kefford, R, Lorigan, P, Mortimer, P, Sabharwal, A, Hayward, O, Margison, G
Natura: Journal article
Lingua:English
Pubblicazione: 2009