Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliabl...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Rubanova, Y, Shi, R, Harrigan, CF, Li, R, Wintersinger, J, Sahin, N, Deshwar, A, PCAWG Evolution and Heterogeneity Working Group, Morris, Q, PCAWG Consortium
مؤلفون آخرون: Wedge, DC
التنسيق: Journal article
اللغة:English
منشور في: Springer Nature 2020