SGC-GAK-1: A chemical probe for cyclin G associated kinase (GAK)

We describe SGC-GAK-1 (11), a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK), together with a structurally related negative control SGC-GAK-1N (14). 11 was highly selective in an in vitro kinome-wide screen, but cellular engagement assays defined RIPK2 as a collater...

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Bibliographic Details
Main Authors:	Asquith, C, Berger, B, Wan, J, Bennett, J, Capuzzi, S, Crona, D, Drewry, D, East, M, Elkins, J, Fedorov, O, Godoi, P, Hunter, D, Knapp, S, Müller, S, Torrice, C, Wells, C, Earp, H, Willson, T, Zuercher, W
Format:	Journal article
Language:	English
Published:	American Chemical Society 2019

SGC-GAK-1: A chemical probe for cyclin G associated kinase (GAK)

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