Regulatory T cells and organ transplantation.
Empirical studies attempting to explain tolerance to transplanted tissues have demonstrated a regulatory role for CD4+ T-cells. We here propose that regulatory T-cells mediating transplantion tolerance comprise two sets which can functionally complement each other. The CD4+CD25+ "natural regula...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1826294789714214912 |
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| author | Waldmann, H Graca, L Cobbold, S Adams, E Tone, M Tone, Y |
| author_facet | Waldmann, H Graca, L Cobbold, S Adams, E Tone, M Tone, Y |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | Empirical studies attempting to explain tolerance to transplanted tissues have demonstrated a regulatory role for CD4+ T-cells. We here propose that regulatory T-cells mediating transplantion tolerance comprise two sets which can functionally complement each other. The CD4+CD25+ "natural regulator" arises in the thymus, and is preoccupied with self-antigens expressed at sites of inflammation. The second, comprising both CD4+CD25+ (FoxP3+) and CD4+CD25- Tr1-like cells are induced by persistent danger-free antigen in the periphery. The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination. |
| first_indexed | 2024-03-07T03:51:06Z |
| format | Journal article |
| id | oxford-uuid:c147fa07-8e08-46d5-84ab-f94db5a03bd7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:51:06Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:c147fa07-8e08-46d5-84ab-f94db5a03bd72022-03-27T06:00:22ZRegulatory T cells and organ transplantation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c147fa07-8e08-46d5-84ab-f94db5a03bd7EnglishSymplectic Elements at Oxford2004Waldmann, HGraca, LCobbold, SAdams, ETone, MTone, YEmpirical studies attempting to explain tolerance to transplanted tissues have demonstrated a regulatory role for CD4+ T-cells. We here propose that regulatory T-cells mediating transplantion tolerance comprise two sets which can functionally complement each other. The CD4+CD25+ "natural regulator" arises in the thymus, and is preoccupied with self-antigens expressed at sites of inflammation. The second, comprising both CD4+CD25+ (FoxP3+) and CD4+CD25- Tr1-like cells are induced by persistent danger-free antigen in the periphery. The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination. |
| spellingShingle | Waldmann, H Graca, L Cobbold, S Adams, E Tone, M Tone, Y Regulatory T cells and organ transplantation. |
| title | Regulatory T cells and organ transplantation. |
| title_full | Regulatory T cells and organ transplantation. |
| title_fullStr | Regulatory T cells and organ transplantation. |
| title_full_unstemmed | Regulatory T cells and organ transplantation. |
| title_short | Regulatory T cells and organ transplantation. |
| title_sort | regulatory t cells and organ transplantation |
| work_keys_str_mv | AT waldmannh regulatorytcellsandorgantransplantation AT gracal regulatorytcellsandorgantransplantation AT cobbolds regulatorytcellsandorgantransplantation AT adamse regulatorytcellsandorgantransplantation AT tonem regulatorytcellsandorgantransplantation AT toney regulatorytcellsandorgantransplantation |