The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa.
Understanding how beneficial mutations affect fitness is crucial to our understanding of adaptation by natural selection. Here, using adaptation to the antibiotic rifampicin in the opportunistic pathogen Pseudomonas aeruginosa as a model system, we investigate the underlying distribution of fitness...
Үндсэн зохиолчид: | Maclean, C, Buckling, A |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
Public Library of Science
2009
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Ижил төстэй зүйлс
Ижил төстэй зүйлс
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The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa.
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Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa.
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Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa.
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Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa.
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Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa.
-н: Gifford, D, зэрэг
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