Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

We report a composite extreme phenotype design using distribution of white matter hyperintensities and brain infarcts in a population-based cohort of older persons for gene-mapping of cerebral small vessel disease. We demonstrate its application in the 3C-Dijon whole exome sequencing (WES) study (n...

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Bibliografiset tiedot
Päätekijät:	Mishra, A, Chauhan, G, Violleau, M, Vojinovic, D, Jian, X, Bis, J, Li, S, Saba, Y, Grenier-Boley, B, Yang, Q, Bartz, T, Hofer, E, Soumaré, A, Peng, F, Duperron, M, Foglio, M, Mosley, T, Schmidt, R, Psaty, B, Launer, L, Boerwinkle, E, Zhu, Y, Mazoyer, B, Lathrop, M, Bellenguez, C, Van Duijn, C, Ikram, M, Schmidt, H, Longstreth, W, Fornage, M, Seshadri, S, Joutel, A, Tzourio, C, Debette, S
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Oxford University Press 2019

Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects

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