How pyroptosis contributes to inflammation and fibroblast-macrophage cross-talk in rheumatoid arthritis

About thirty years ago, a new form of pro-inflammatory lytic cell death was observed and termed pyroptosis. Only in 2015, gasdermins were defined as molecules that create pores at the plasma membrane and drive pyroptosis. Today, we know that gasdermin-mediated death is an important antimicrobial def...

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Bibliographic Details
Main Authors: Demarco, B, Danielli, S, Fischer, FA, Bezbradica, JS
Format: Journal article
Language:English
Published: MDPI 2022