ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

Show other versions (1)

The deubiquitylation enzyme USP7/HAUSP plays a major role in regulating genome stability and cancer prevention by controlling the key proteins involved in the DNA damage response. Despite this important role in controlling other proteins, USP7 itself has not been recognized as a target for regulatio...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Khoronenkova, S, Dianova, I, Ternette, N, Kessler, B, Parsons, J, Dianov, G
פורמט:	Journal article
שפה:	English
יצא לאור:	2012

פריטים דומים

ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
מאת: Khoronenkova, S, et al.
יצא לאור: (2012)

Regulation of USP7/HAUSP in response to DNA damage: yet another role for ATM.
מאת: Khoronenkova, S, et al.
יצא לאור: (2012)

USP7/HAUSP stimulates repair of oxidative DNA lesions.
מאת: Khoronenkova, S, et al.
יצא לאור: (2011)

USP7/HAUSP promotes the sequence-specific DNA binding activity of p53.
מאת: Feroz Sarkari, et al.
יצא לאור: (2010-09-01)

Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.
מאת: Parsons, J, et al.
יצא לאור: (2012)

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.
מאת: Khoronenkova, S, et al.
יצא לאור: (2013)

Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.
מאת: Kessler, B, et al.
יצא לאור: (2007)

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
מאת: Parsons, J, et al.
יצא לאור: (2011)

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
מאת: Min Hu, et al.
יצא לאור: (2006-02-01)

Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
יצא לאור: (2006-01-01)

ARF induction in response to DNA strand breaks is regulated by PARP1
מאת: Orlando, G, et al.
יצא לאור: (2013)

PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6
מאת: Jae-Sung Kim, et al.
יצא לאור: (2022-04-01)

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
מאת: Stephanie J Papp, et al.
יצא לאור: (2015-03-01)

Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
מאת: Jun Tang, et al.
יצא לאור: (2013-01-01)

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.
מאת: Parsons, J, et al.
יצא לאור: (2008)

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
יצא לאור: (2013-01-01)

Correction: Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation.
מאת: Jun Tang, et al.
יצא לאור: (2013-01-01)

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
מאת: Parsons, J, et al.
יצא לאור: (2009)

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair.
מאת: Parsons, J, et al.
יצא לאור: (2005)

APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.
מאת: Parsons, J, et al.
יצא לאור: (2005)

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
מאת: Konstantinos Karakostis, et al.
יצא לאור: (2024-01-01)

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM.
מאת: Enoch, T, et al.
יצא לאור: (1995)

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
מאת: Parsons, J, et al.
יצא לאור: (2005)

The emerging role of Mule and ARF in the regulation of base excision repair.
מאת: Khoronenkova, S, et al.
יצא לאור: (2011)

The emerging role of Mule and ARF in the regulation of base excision repair
מאת: Khoronenkova, S, et al.
יצא לאור: (2011)

USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM
מאת: Ruiqiu Zhu, et al.
יצא לאור: (2024-11-01)

Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy
מאת: Lianhui Sun, et al.
יצא לאור: (2025-02-01)

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
מאת: Meisenberg, C, et al.
יצא לאור: (2012)

Expression of Tp53 and USP7 during development of lungs in mouse model
מאת: Mushtaq Hussain, et al.
יצא לאור: (2020-12-01)

Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
מאת: Parsons, J, et al.
יצא לאור: (2005)

Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.
מאת: Woodhouse, B, et al.
יצא לאור: (2008)

ATM and Chk2 kinase target the p53 cofactor Strap.
מאת: Adams, C, et al.
יצא לאור: (2008)

Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway.
מאת: Alberto Valbuena, et al.
יצא לאור: (2011-02-01)

miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase.
מאת: Libing Song, et al.
יצא לאור: (2011-01-01)

APE1 is the major 3'-phosphoglycolate activity in human cell extracts.
מאת: Parsons, J, et al.
יצא לאור: (2004)

PPM1G promotes cell proliferation via modulating mutant GOF p53 protein expression in hepatocellular carcinoma
מאת: Wen Hu, et al.
יצא לאור: (2024-03-01)

Monitoring base excision repair proteins on damaged DNA using human cell extracts.
מאת: Parsons, J, et al.
יצא לאור: (2004)

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
מאת: Anamarija Jurisic, et al.
יצא לאור: (2024-04-01)

USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53
מאת: Xue Li, et al.
יצא לאור: (2024-09-01)

Phosphorylation of the DNA damage repair factor 53BP1 by ATM kinase controls neurodevelopmental programs in cortical brain organoids.
מאת: Bitna Lim, et al.
יצא לאור: (2024-09-01)