A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency

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Superparamagnetic iron oxide nanoparticles (SPIONs) have mainly been used as cellular carriers for genes and therapeutic products, while their use in subcellular organelle isolation remains underexploited. We engineered SPIONs targeting distinct subcellular compartments. Dimercaptosuccinic acid-coat...

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Bibliographic Details
Main Authors: Tharkeshwar, A, Trekker, J, Vermeire, W, Pauwels, J, Sannerud, R, Priestman, D, Te Vruchte, D, Vints, K, Baatsen, P, Decuypere, J, Li, H, Martin, S, Vangheluwe, P, Swinnen, J, Lagae, L, Impens, F, Platt, F, Gevaert, K, Annaert, W
Format: Journal article
Published: Nature Publishing Group 2017

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