Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system.

Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system.

In plasmodia, the dihydrofolate reductase (DHFR) enzyme is the target of the pyrimethamine component of sulfadoxine-pyrimethamine (S/P). Plasmodium vivax infections are not treated intentionally with antifolates. However, outside Africa, coinfections with Plasmodium falciparum and P. vivax are commo...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Hastings, MD, Maguire, J, Bangs, M, Zimmerman, P, Reeder, J, Baird, J, Sibley, C
Format:	Journal article
Sprache:	English
Veröffentlicht:	2005

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