The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium falciparum strain is exposed to ART derivatives such as dihyd...

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Autors principals: Dembele, L, Ang, X, Chavchich, M, Bonamy, GMC, Selva, JJ, Lim, MY, Bodenreider, C, Yeung, BKS, Nosten, F, Russell, BM, Edstein, MD, Straimer, J, Fidock, DA, Diagana, TT, Bifani, P
Format: Journal article
Idioma:English
Publicat: Springer Nature 2017