Generation of bivalent chromatin domains during cell fate decisions.

Generation of bivalent chromatin domains during cell fate decisions.

BACKGROUND: In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell...

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Bibliographic Details
Main Authors: De Gobbi, M, Garrick, D, Lynch, M, Vernimmen, D, Hughes, J, Goardon, N, Luc, S, Lower, K, Sloane-Stanley, J, Pina, C, Soneji, S, Renella, R, Enver, T, Taylor, S, Jacobsen, SE, Vyas, P, Gibbons, R, Higgs, D
Format: Journal article
Language:English
Published: 2011

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