Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet, the underlying mechanisms are...

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Detalles Bibliográficos
Main Authors: Van Den Beucken, T, Koch, E, Chu, K, Rupaimoole, R, Prickaerts, P, Adriaens, M, Voncken, JW, Harris, AL, Buffa, FM, Haider, S, Starmans, MHW, Yao, CQ, Ivan, M, Ivan, C, Pecot, CV, Boutros, PC, Sood, AK, Koritzinsky, M, Wouters, BG
Formato: Journal article
Idioma:English
Publicado: Springer Nature 2014