Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

MicroRNAs are small regulatory RNAs that post transcriptionally control gene expression. Reduced expression of DICER, the enzyme involved in microRNA processing, is frequently observed in cancer and is associated with poor clinical outcome in various malignancies. Yet, the underlying mechanisms are...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Van Den Beucken, T, Koch, E, Chu, K, Rupaimoole, R, Prickaerts, P, Adriaens, M, Voncken, JW, Harris, AL, Buffa, FM, Haider, S, Starmans, MHW, Yao, CQ, Ivan, M, Ivan, C, Pecot, CV, Boutros, PC, Sood, AK, Koritzinsky, M, Wouters, BG
Format: Journal article
Sprache:English
Veröffentlicht: Springer Nature 2014

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