The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA.

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA.

The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interfer...

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Bibliographic Details
Main Authors: Mannion, N, Greenwood, S, Young, R, Cox, S, Brindle, J, Read, D, Nellåker, C, Vesely, C, Ponting, C, McLaughlin, P, Jantsch, M, Dorin, J, Adams, I, Scadden, A, Ohman, M, Keegan, L, O'Connell, M
Format: Journal article
Language:English
Published: Elsevier 2014

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