A model-based approach to capture genetic variation for future association studies.

A model-based approach to capture genetic variation for future association studies.

Genome-wide association studies are still constrained by the cost of genotyping. For this reason, the selection of a reduced set of markers or tags able to capture a significant proportion of the genetic variation is an important aspect of these studies. Most tagging SNP selection methods have been...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Eyheramendy, S, Marchini, J, McVean, G, Myers, S, Donnelly, P
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2007

Antzeko izenburuak

A new multipoint method for genome-wide association studies by imputation of genotypes.
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Estimating meiotic gene conversion rates from population genetic data.
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A common sequence motif associated with recombination hot spots and genome instability in humans.
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Perspectives on human genetic variation from the HapMap Project.
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Perspectives on human genetic variation from the HapMap project
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PRDM9 marks the spot.
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Recombination Rates, their local variation and the estimated number of hotspots in the human genome.
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The influence of recombination on human genetic diversity.
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The influence of recombination on human genetic diversity.
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The structure of linkage disequilibrium around a selective sweep.
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The fine-scale structure of recombination rate variation in the human genome.
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The impact of age on genetic risk for common diseases
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The impact of age on genetic risk for common diseases.
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The distribution and causes of meiotic recombination in the human genome.
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Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
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An integrated map of genetic variation from 1,092 human genomes.
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Genomewide association studies and common disease--realizing clinical utility.
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Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.
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The influence of mutation, recombination, population history, and selection on patterns of genetic diversity in Neisseria meningitidis.
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Graphical model selection for Gaussian conditional random fields in the presence of latent variables
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A coalescent-based method for detecting and estimating recombination from gene sequences.
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Recombination rate estimation in the presence of hotspots.
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A structured ancestral population for the evolution of modern humans.
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Differential confounding of rare and common variants in spatially structured populations
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Estimating Selection Coefficients in Spatially Structured Populations from Time Series Data of Allele Frequencies
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Estimating diversifying selection and functional constraint in the presence of recombination.
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