Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package

Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package

A description of the materials and methods is included within the TEP datasheet. Cyclin-dependent kinase 12 (CDK12) phosphorylates RNA Pol II C-terminal domain (CTD) to promote transcriptional elongation of large DNA damage response genes. CDK12 is frequently mutated or amplified in cancer and its l...

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Dettagli Bibliografici
Altri autori:	Bullock, A
Natura:	Dataset
Pubblicazione:	University of Oxford 2018
Soggetti:	Chemical Biology Structural Genomics Drug Discovery

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