Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.

Interaction of the T cell receptor (TCR) with peptide/major histocompatibility complexes (MHC) in the thymus is of critical importance for developing thymocytes. In a previous study, we described an antagonist peptide that inhibited negative selection of transgenic thymocytes induced by an agonist p...

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Bibliographic Details
Main Authors: Smyth, L, Williams, O, Huby, R, Norton, T, Acuto, O, Ley, S, Kioussis, D
Format: Journal article
Language:English
Published: 1998