Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases sampled at autopsy from a treatment naïve patient and by leveraging the...

Full description

Bibliographic Details
Main Authors: Rabbie, R, Ansari-Pour, N, Cast, O, Lau, D, Scott, F, Welsh, SJ, Parkinson, C, Khoja, L, Moore, L, Tullett, M, Wong, K, Ferreira, I, Gómez, JMM, Levesque, M, Gallagher, FA, Jiménez-Sánchez, A, Riva, L, Miller, ML, Allinson, K, Campbell, PJ, Corrie, P, Wedge, DC, Adams, DJ
Format: Journal article
Language:English
Published: Nature 2020