The role of B27 heavy chain dimer immune receptor interactions in spondyloarthritis.
HLA-B27 (B27) is strongly associated with spondyloarthopathy. The classical role of B27 is to present peptides from intracellular pathogens as a heterotrimeric complex with beta2 microglobulin for recognition by the T-cell receptor (TCR) of CD8 T-cells. In addition to heterotrimers, B27 can also be...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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