The robustness of proofreading to crowding-induced pseudo-processivity in the MAPK pathway

Double phosphorylation of protein kinases is a common feature of signalling cascades. This motif may reduce cross-talk between signalling pathways, as the second phosphorylation site allows for proofreading, especially when phosphorylation is distributive rather than processive. Recent studies sugge...

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Bibliographic Details
Main Authors: Ouldridge, T, Wolde, P
Format: Journal article
Published: 2014