Extracellular matrix-mediated chemotaxis can impede cell migration

Cells use a combination of changes in adhesion, proteolysis and motility (directed and random) during the process of migration. Proteolysis of the extracellular matrix (ECM) results in the creation of haptotactic gradients, which cells use to move in a directed fashion. The proteolytic creation of t...

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Bibliographic Details
Main Authors: Perumpanani, A, Simmons, D, Gearing, A, Miller, K, Ward, G, Norbury, J, Schneemann, M, Sherratt, J
Format: Journal article
Language:English
Published: 1998