Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
The cystic fibrosis conductance regulator (CFTR) is a cAMP-regulated Cl(-) channel expressed predominantly at the apical membrane of secreting epithelial cells. Mutations in the CFTR gene lead to cystic fibrosis, the most frequent genetic disease in the Caucasian population. The most common mutation...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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