Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.

The ultimate step in the biosynthesis of the medicinally important beta-lactamase inhibitor clavulanic acid is catalyzed by clavulanic acid dehydrogenase (CAD). CAD is responsible for the NAPDH-dependent reduction of the unstable intermediate clavulanate-9-aldehyde to yield clavulanic acid. Here, we...

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Bibliografiske detaljer
Main Authors: MacKenzie, A, Kershaw, N, Hernandez, H, Robinson, C, Schofield, C, Andersson, I
Format: Journal article
Sprog:English
Udgivet: 2007