The MBP fusion protein restores the activity of the first phosphatase domain of CD45.

CD45 is a receptor-like protein tyrosine phosphatase critically involved in the regulation of initial effector functions in B- and T-cells. The protein comprises two phosphatase (PTP) domains in its cytoplasmic region. However, whether each PTP domain has enzyme activity by itself or whether both do...

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Bibliographic Details
Main Authors: Lorenzo, H, Farber, D, Germain, V, Acuto, O, Alzari, P
Format: Journal article
Language:English
Published: 1997