The MBP fusion protein restores the activity of the first phosphatase domain of CD45.
CD45 is a receptor-like protein tyrosine phosphatase critically involved in the regulation of initial effector functions in B- and T-cells. The protein comprises two phosphatase (PTP) domains in its cytoplasmic region. However, whether each PTP domain has enzyme activity by itself or whether both do...
Main Authors: | Lorenzo, H, Farber, D, Germain, V, Acuto, O, Alzari, P |
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Format: | Journal article |
Language: | English |
Published: |
1997
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