NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

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A cytotoxic T lymphocyte (CTL) kills an infected or tumorigenic cell by Ca(2+)-dependent exocytosis of cytolytic granules at the immunological synapse formed between the two cells. Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from the endoplasmic reticulum activates the stor...

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Bibliographic Details
Main Authors: Davis, L, Morgan, A, Chen, J, Snead, C, Bloor-Young, D, Shenderov, E, Stanton-Humphreys, M, Conway, S, Churchill, G, Parrington, J, Cerundolo, V, Galione, A
Format: Journal article
Language:English
Published: 2012

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