Induction and repair of clustered DNA lesions: what do we know so far?

The accumulated evidence in the literature indicates that a cluster of two or more lesions within one or two helical turns of the DNA is more challenging to repair than individual, widely dispersed lesions. The biological importance of clustered DNA lesions, especially complex double-strand breaks (...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Georgakilas, A, O'Neill, P, Stewart, R
Format: Journal article
Sprache:English
Veröffentlicht: 2013