Tetrahydrocarbazoles are a novel class of potent P-type ATPase inhibitors with antifungal activity

<p>We have identified a series of tetrahydrocarbazoles as novel P-type ATPase inhibitors. Using a set of rationally designed analogues, we have analyzed their structure-activity relationship using functional assays, crystallographic data and computational modeling. We found that tetrahydrocarb...

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Detalhes bibliográficos
Principais autores: Bublitz, M, Kjellerup, L, O'Hanlon Cohrt, K, Gordon, S, Mortensen, AL, Clausen, JD, Pallin, TD, Hansen, JB, Fuglsang, AT, Dalby-Brown, W, Winther, A-ML
Formato: Journal article
Idioma:English
Publicado em: Public Library of Science 2018