Structural analysis of inhibitor binding to CAMKK1 identifies features necessary for design of specific inhibitors

The calcium/calmodulin-dependent protein kinases (CAMKKs) are upstream activators of CAMK1 and CAMK4 signalling and have important functions in neural development, maintenance and signalling, as well as in other aspects of biology such as Ca2+ signalling in the cardiovascular system. To support the...

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Bibliographic Details
Main Authors: Santiago, A, Couñago, R, Ramos, P, Godoi, P, Massirer, K, Gileadi, O, Elkins, J
Format: Journal article
Language:English
Published: Nature Publishing Group 2018