A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses.

Virus like particles (VLPs) are known to induce potent B cell responses in the absence of adjuvants. Moreover, epitope-specific antibody responses may be induced by VLPs that contain peptides inserted in their immunodominant regions. However, due to steric problems, the size of the peptides capable...

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Bibliographic Details
Main Authors: Jegerlehner, A, Tissot, A, Lechner, F, Sebbel, P, Erdmann, I, Kündig, T, Bächi, T, Storni, T, Jennings, G, Pumpens, P, Renner, W, Bachmann, M
Format: Journal article
Language:English
Published: 2002