A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6). We...

ver descrição completa

Detalhes bibliográficos
Principais autores:	Khor, C, Chapman, S, Vannberg, F, Dunne, A, Murphy, C, Ling, E, Frodsham, A, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, C, Knox, K, Campbell, S, Lienhardt, C, Scott, A, Aaby, P, Sow, O, Grignani, RT, Sillah, J, Sirugo, G, Peshu, N, Williams, T, Maitland, K
Formato:	Journal article
Idioma:	English
Publicado em:	2007

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Registros relacionados