A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis.

Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6). We...

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Bibliographic Details
Main Authors: Khor, C, Chapman, S, Vannberg, F, Dunne, A, Murphy, C, Ling, E, Frodsham, A, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, C, Knox, K, Campbell, S, Lienhardt, C, Scott, A, Aaby, P, Sow, O, Grignani, RT, Sillah, J, Sirugo, G, Peshu, N, Williams, T, Maitland, K
Format: Journal article
Language:English
Published: 2007

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