Homodimerisation of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium
The lymphatic vessel endothelial receptor LYVE-1 is implicated in uptake of hyaluronan (HA) and trafficking of leucocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan, and depends on receptor clustering and higher-order ligand organisation for durable binding in lymphati...
| প্রধান লেখক: | , , , , , , , , |
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| বিন্যাস: | Journal article |
| প্রকাশিত: |
American Society for Biochemistry and Molecular Biology
2016
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