HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells.

Non-classical MHC class I molecule HLA-E is the ligand for CD94/NKG2 NK cell receptors. Surface expression of HLA-E requires binding of specific HLA class I leader sequences. The uterine mucosa in early pregnancy (decidua) is infiltrated by large numbers of NK cells, which are closely associated wit...

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Bibliografiska uppgifter
Huvudupphovsmän: King, A, Allan, D, Bowen, M, Powis, S, Joseph, S, Verma, S, Hiby, SE, Mcmichael, A, Loke, Y, Braud, V
Materialtyp: Journal article
Språk:English
Publicerad: 2000