Quantifying the heterogeneity of macromolecular machines by mass photometry

Quantifying the heterogeneity of macromolecular machines by mass photometry

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Sample purity is central to in vitro studies of protein function and regulation, and to the efficiency and success of structural studies using techniques such as x-ray crystallography and cryo-electron microscopy (cryo-EM). Here, we show that mass photometry (MP) can accurately characterize the hete...

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Príomhchruthaitheoirí:	Sonn-Segev, A, Belacic, K, Bodrug, T, Young, G, VanderLinden, RT, Schulman, BA, Schimpf, J, Friedrich, T, Dip, PV, Schwartz, TU, Bauer, B, Peters, J-M, Benesch, JLP, Struwe, WB, Brown, NG, Haselbach, D, Kukura, P
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Springer Nature 2020
Ábhair:	Cryoelectron microscopy Structural biology Single-molecule biophysics High-throughput screening

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